Ifitm1 and cancer

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Web28 aug. 2024 · Targeting IFITM1 by siRNA or CRISPR/Cas9 in TNBC cell lines significantly inhibits proliferation, colony formation, and wound healing in vitro. … Web7 jan. 2024 · IFITM1 promotes homotypic adhesion of lymphocytes and inhibits proliferation of the B cell lineage [ 14, 15 ]. In addition, IFITM1 has been implicated in the migration, invasion, and proliferation of cancer cells [ 16, 17] but can also inhibit tumor cell growth [ 18 ].

IFITM1 Gene - GeneCards IFM1 Protein IFM1 Antibody

Web7 jul. 2024 · We have shown that IFITM1-expressing breast cancer cells produce type 1 IFNs and stimulate IFITM1 production in an autocrine manner, but outside of DNA damage resistance, little is understood about the mechanism by which IFITM1 influences the breast cancer cell phenotype [14, 53]. Traditionally, the orthotopic model is used to evaluate … WebIn colon (4), breast (19), and lung cancers (20), IFITM1 is highly expressed and has a cancer-promoting effect. However, IFITM1 has a low expression in cervical squamous cell carcinoma and a... imi global ranch shipping certificate

The IFITM protein family in adaptive immunity - Yánez - 2024 ...

Web21 mrt. 2024 · IFITM1 (Interferon Induced Transmembrane Protein 1) is a Protein Coding gene. Diseases associated with IFITM1 include Influenza and West Nile Virus . Among … WebIn molecular biology, housekeeping genes are typically constitutive genes that are required for the maintenance of basic cellular function, and are expressed in all cells of an organism under normal and patho … Web7 jul. 2024 · IFITM1 knockdown diminishes AI-resistant tumor growth and invasion in vivo which is associated with changes in CD31+ blood vessel density and matrix … imiglucerase production

SRSF1 as a novel interacting partner for IFITM1/3 unravels

Down-regulation of IFITM1 and its growth inhibitory role in …

Web10 okt. 2024 · IFITM1 mRNA level was measured by real-time quantitative RT-PCR in cervical cancer tissues and their adjacent normal tissues. IFITM1 protein level was … Web29 mrt. 2024 · Emergent Role of IFITM1/3 towards Splicing Factor (SRSF1) and Antigen-Presenting Molecule (HLA-B) in Cervical Cancer. Differential Leukocyte Expression of IFITM1 and IFITM3 in Patients with Severe Pandemic Influenza A (H1N1) and COVID-19. Impact of interferon-induced transmembrane protein 3 gene rs12252 polymorphism on … i migliori network marketing in italiaWeb27 okt. 2024 · IFITM proteins have been linked to most hallmarks of cancer, including tumor cell proliferation, therapeutic resistance, angiogenesis, invasion, and metastasis. Recent studies have described the involvement of IFITM proteins in antitumor immunity. i migliori software player cda

"Web1 jan. 2024 · Furthermore, IFITM1/IFITM3 double KO cells had a reduced 80S ribosomal fraction, while IFITM proteins could be detected in polysomes. Notably, genetic KO of IFITM1 and IFITM3 inhibited the synthesis of a subset of IFN-responsive proteins, which is consistent with the notion of an immunoregulatory role for IFITMs in cancer (Fig. 3). " - Ifitm1 and cancer

Ifitm1 and cancer

IFITM proteins: Understanding their diverse roles in viral infection ...

WebIFITM1. General description of the gene and the encoded protein (s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project. … Web12 dec. 2024 · In this study, we presented evidence that IFITM1 was highly expressed in lung cancer tissues and cell lines. IFITM1 silencing inhibited lung cancer cell proliferation, migration, and invasion in vitro. Furthermore, the in vivo experiments showed that IFITM1 silencing inhibited lung cancer cell growth and metastasis.

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Web23 sep. 2024 · IFITM1, CD10, SMA, and h-caldesmon are a good combination for the differential diagnosis of EST and CL. The differential diagnosis of endometrial stromal tumor (EST) and uterine cellular leiomyoma (CL) remains a challenge in clinical practice, especially low grade endometrial stromal sarcoma (ESS) and CL, suggesting the need for novel … WebInterferon-induced transmembrane proteins IFITM1 and IFITM3 (IFITM1/3) play a role in both RNA viral restriction and in human cancer progression. Using …

Web30 sep. 2008 · As all cancer cases expressed IFITM1 at higher levels, we could not compare with clinicopathologic findings, including histologic differentiation and metastasis. Thus, high expression of IFITM1 was focally observed in invasive front of early invasive HNSCC and diffusely observed in invasive HNSCC. http://www.cancer-genetics.org/IFITM1.htm

Web14 dec. 2024 · Pan-cancer analysis of the prognostic value of IFITM1. We assessed the prognostic value of IFITM1 in multiple types of cancer. As shown in Supplementary Figure S6, Kaplan–Meier survival analysis revealed that the low expression of IFITM1 was associated with poor overall survival in BRCA (p = 0.031); the upregulation of IFITM1 … Webwww.ncbi.nlm.nih.gov

WebMy Masters by research project at the Edinburgh Cancer Research Centre focused on “The Development of Monoclonal Antibodies to IFITM1 …

Web18 jul. 2024 · Dynamic interaction between prostate cancer and the bone microenvironment is a major contributor to metastasis of prostate cancer to bone. In this study, we utilized an in vitro co-culture model of PC3 prostate cancer cells and osteoblasts followed by microarray based gene expression profiling to identify previously unrecognized prostate … list of properties owned by the royal familyWeb2 dec. 2024 · Interferon-inducible transmembrane (IFITM) proteins are a family of small homologous proteins, localized in the plasma and endolysosomal membranes, which confer cellular resistance to many viruses. In addition, several distinct functions have been associated with different IFITM family members, including germ cell specification … imig mesothelioma list of property agents in singaporeWeb5 okt. 2024 · IFITM1 high and IFITM1 low CRC cells do not differ in their intensity of EV release. The IFITM1 cell surface protein is involved in inhibiting the uptake of some … imig meaning in textWebIn a previous study, we showed that IFITM1 is involved in the immune escape and metastasis of gastric cancer cells. In this study, we determined the difference in … imigmob conference st andrewsWeb15 jan. 2015 · To determine the functional significance of IFITM1 and PLSCR1 in AI-resistant MCF-7:5C breast cancer cells, we transiently transfected MCF-7:5C cells with … list of property developers in gautengWeb12 apr. 2024 · Many ovarian cancer biomarkers are reviewed and validated through bioinformatics tools. Different genes were discovered and validated using GEO and common DEGs through cBioPortal, KEGG, functional enrichment analysis, PPI, and oncomine along with immunohistology. Many hub genes were found and reviewed using common DEGs … imig music building