Topbp1 cancer
Web12. sep 2014 · The expression levels of TopBP1 and Claspin were increased in the cancer cells that survived radiation therapy. Depletion of TopBP1 or Claspin using shRNA showed an enhancement of sensitivity to radiation in radioresistant lung cancer cells (PC14PE6). Moreover, increased levels of TopBP1 or Claspin endowed cells a higher resistance to … WebTOPBP1 is not prognostic in lung cancer Alive (n=600) Dead (n=394) Female (n=398) Male (n=596) Stage: i (n=8) ia (n=219) ib (n=283) ii (n=4) iia (n=114) iib (n=159) iii (n=3) iiia …
Topbp1 cancer
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WebTOPBP1 PATHOLOGY CANCER ANTIBODIES AND VALIDATION Dictionary Human pathology PROGNOSTIC SUMMARYi Prognostic marker in liver cancer (unfavorable), endometrial cancer (unfavorable) and pancreatic cancer (unfavorable) WebTOPBP1 PATHOLOGY CANCER ANTIBODIES AND VALIDATION Dictionary Human pathology PROGNOSTIC SUMMARYi Prognostic marker in liver cancer (unfavorable), endometrial …
WebPatients were divided based on level of expression into one of the two groups "low" (under cut off) or "high" (over cut off). X-axis shows time for survival (years) and y-axis shows the probability of survival, where 1.0 corresponds to 100 percent. Read more. TOPBP1 is not prognostic in prostate cancer. Web28. feb 2007 · Aims: The TopBP1 protein includes eight BRCT domains (originally identified in BRCA1) and has homology with BRCA1 over the carboxyl terminal half of the protein. The aim of this study was to determine whether TopBP1 is aberrantly expressed in breast cancer. Methods and results: Sixty‐one breast carcinomas from an unselected …
Webpred 15 minútami · Ovarian cancer has a specific unmet clinical need, with a persistently poor 5-year survival rate observed in women with advanced stage disease warranting continued efforts to develop new treatment options. The amplification of BRD4 in a significant subset of high-grade serous ovarian carcinomas (HGSC) has led to the … Web31. aug 2024 · Here, we demonstrate that CIP2A is selectively essential for DNA damage-induced initiation of mouse BLBC tumors, but not of other cancer types. Mechanistically, …
WebTopBP1 also acts as a transcriptional regulator, and we investigated how this activity influenced the HPV life cycle. We determined that TopBP1 levels are increased in cervical …
WebTOPBP1 (Dpb11, KIAA0259, TOP2BP1) protein expression summary. We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. ... Prognostic marker in liver cancer (unfavorable), endometrial cancer (unfavorable) and pancreatic cancer (unfavorable) Liver cancer p0.001. Cancer ... kaddish for an unborn childWeb28. apr 2012 · TopBP1 possesses eight BRCA1 (breast cancer gene 1) carboxyl-terminal (BRCT) domains which were for the first time described for BRCA1 protein and are commonly found in proteins involved in regulation of the cell cycle checkpoint and the response of the cell to DNA damage [ 1, 3 – 5 ]. lawayne america holdingsWeb12. sep 2014 · The expression levels of TopBP1 and Claspin were increased in the cancer cells that survived radiation therapy. Depletion of TopBP1 or Claspin using shRNA showed … kaddish transliteration english printableWeb1. máj 2024 · TopBP1 serves as a scaffold to assemble protein complexes in a phosphorylation-dependent manner via its multiple BRCT-repeats. Recently, it has become clear that TopBP1 is repurposed to scaffold different processes dependent on cell cycle regulated changes in phosphorylation of client proteins. kaddish shalem transliteration prayer pdfWebExpression of TOPBP1 (Dpb11, KIAA0259, TOP2BP1) in cancer tissue. The cancer tissue page shows antibody staining of the protein in 20 different cancers. kaddish transliteration sephardicWeb8. feb 2024 · Finally, physical disruption of the CIP2A-TOPBP1 complex is highly deleterious in BRCA-deficient cells and tumors, indicating that targeting this mitotic chromosome stability process represents an attractive synthetic-lethal therapeutic strategy for BRCA1 - and BRCA2 -mutated cancers. Competing Interest Statement lawayne bontragerWebObjective: Topoisomerase IIβ binding protein 1 (TopBP1) is involved in DNA damage and replication checkpoint and has been shown to be related to tumorigenesis in many … kaddish transliteration printable